pentobarbital will lessen the extent or outcome of methylprednisolone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.Contraindicated (1)pentobarbital will decrease the extent or effect of roflumilast by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lower the level or effect of cyclosporine by